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Before starting lisdexamfetamine, read the Medication Guide your pharmacist gives you, and review it again with each refill. Speak with your doctor or pharmacist if you have any concerns.

Take this medication in the morning, with or without food, as your doctor instructs — once a day is typical. Avoid taking it in the afternoon or evening, as it can interfere with sleep. Your doctor will determine the right dose for your situation and may make adjustments over time. Follow their guidance closely.

For the chewable tablet, chew it fully before swallowing. For the capsule, swallow it whole if possible. If swallowing is difficult, open the capsule and mix the powder into a glass of water, orange juice, or yogurt. Stir until fully dissolved, then consume it immediately — don’t prepare it ahead of time. A thin film left on the inside of the glass or container afterward is completely normal.

Take the medication consistently and at the same time each day to get the best results.

Your doctor may periodically suggest a brief pause in treatment to evaluate whether the medication is still necessary and whether your behavior has changed.

Stopping this medication abruptly can lead to withdrawal symptoms, including extreme fatigue, sleep disturbances, or mood changes like depression. To reduce this risk, your doctor will likely taper your dose gradually — especially if you’ve been taking it at high doses or for an extended period. Notify your doctor or pharmacist promptly if you experience any withdrawal effects.

While this medication is beneficial for many people, there is some risk of dependency, particularly for those with a history of substance misuse. Do not exceed your prescribed dose, take it more frequently than directed, or continue it longer than recommended. Stop only as instructed by your doctor.

If the medication seems less effective over time, let your doctor know so they can reassess your treatment.

Before starting lisdexamfetamine, read the Medication Guide your pharmacist gives you, and review it again with each refill. Speak with your doctor or pharmacist if you have any concerns. Click to view more

Some common side effects include nausea, vomiting, constipation, stomach pain, reduced appetite, dry mouth, headache, nervousness, dizziness, difficulty sleeping, sweating, weight loss, irritability, and restlessness. If any of these continue or get worse, let your doctor or pharmacist know.

Your doctor prescribed this medication because the expected benefits outweigh the potential risks. Most people who take it do not experience serious side effects.

This medication can elevate blood pressure, so monitor it regularly and inform your doctor if readings are high.

Contact your doctor immediately if you notice any serious side effects, such as blurred vision, a rapid or irregular heartbeat, mental or behavioral changes (including agitation, aggression, mood swings, depression, hallucinations, unusual thoughts or behavior, or thoughts of self-harm), uncontrolled movements or muscle twitching, signs of poor circulation in the fingers or toes (such as coldness, numbness, pain, or discoloration), unexplained sores on the fingers or toes, sudden verbal outbursts, changes in sexual desire or function, swollen ankles or feet, severe fatigue, unexplained rapid weight loss, or prolonged erections in males.

Seek emergency medical attention immediately if you experience shortness of breath, fainting, chest, jaw, or left arm pain, seizures, one-sided weakness, slurred speech, confusion, or sudden changes in vision.

In rare cases, this medication can elevate serotonin levels and lead to a serious condition known as serotonin syndrome. The risk is higher if you are also taking other medications that affect serotonin — so be sure to inform your doctor or pharmacist of everything you take. Seek immediate medical care if you develop a rapid heartbeat, hallucinations, loss of coordination, severe dizziness, significant nausea, vomiting or diarrhea, muscle twitching, an unexplained fever, or unusual agitation.

Severe allergic reactions are rare but require immediate medical attention. Watch for symptoms such as a rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing.

This is not an exhaustive list of possible side effects. Report any unlisted effects to your doctor or pharmacist. In the US, you can also report side effects to the FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

Missed Doses: If you forget a dose, take it as soon as you recall — but only if it’s still morning. If it’s already afternoon or close to your next scheduled dose, skip the missed one and resume your regular dosing schedule. Never take a double dose to make up for the one you missed. Notes: Do not give this medication to anyone else, as doing so is illegal. Your doctor may periodically order lab work or medical evaluations — such as blood pressure checks, heart rate monitoring, or growth assessments in children — to track your progress and watch for any side effects. Ask your doctor if you have questions about what to expect.